Altered metabolic requirements in cancer cell migration and metastasis
نویسندگان
چکیده
Background Metastasis poses a great challenge in clinical management of many cancers. Metabolic demands of cancer cell proliferation – i.e. elevated aerobic glycolysis for biomass generation – have been well characterized, but the contribution of altered metabolism to metastasis remains to be elucidated. While elevated aerobic glycolysis, a phenomenon termed Warburg effect, is a hallmark of proliferative tumor cells, emerging evidence suggests that metastatic cancer cells have an opposite phenotype.
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